• quotes_open...a category of bacteria that by some estimates are already killing tens of thousands of hospital patients each year.quotes_close

    Source: Pollack A. "A Rising Hospital Threat." The New York Times. Feb 27, 2010

  • quotes_openIn many respects it's far worse than MRSA. There are strains out there, and they are becoming more and more common, that are resistant to virtually every antibiotic we have.quotes_close

    Dr. Louis B. Rice, ID Specialist at Louis Stokes Cleveland Medical Center and Case Western Reserve University

  • quotes_openThe fears for the dawn of a post-antibiotic era, at least for the three [Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae] Gram-negative isolates evaluated in this review, appear to be justified.quotes_close

    Matthew E. Falagas, Ioannis A. Bliziotis, “Pandrug-resistant Gram-negative bacteria: the dawn of the post-antibiotic era?”, International Journal of Antimicrobial Agents, Volume 29, Issue 6, June 2007, Pages 630-636

  • quotes_open Infectious diseases physicians are alarmed by the prospect that effective antibiotics may not be available to treat seriously ill patients in the near future. There simply aren’t enough new drugs in the pharmaceutical pipeline to keep pace with drug-resistant bacterial infections, so-called ‘superbugs.’quotes_close

    Joseph R. Dalovisio, MD, IDSA President,(From “Bad Bugs, No Drugs”), July 2004

  • quotes_openFor Gram-positives, we need better drugs; for Gram-negatives, we need any drugs.quotes_close

    Dr. Brad Spellberg, ID Specialist at Harbor UCLA Medical Center

The Threat is Real

There is increased concern about the public health threat caused by infections due to a growing array of multi-drug-resistant (MDR) bacteria. This site brings together the views of physicians, scientists, policy experts and others about the problem and what we can do about it.



A conversation with Dr. Edward J. Septimus, M.D.
Professor Internal Medicine Texas A&M
Health Science Center College of Medicine

Dr. Septimus discusses public health threat posed by antibiotic resistance Gram-negative bacteria & the potential to be entering into a “pre-antibiotic era” & the challenges ahead in new antibiotic development. (3:26)


The Complexity of Antibiotic Resistance


Drug resistant bacteria


Gram-negative pathogens

Meeting the Challenge

A new group of superbugs, which may prove to be more dangerous than MRSA, is now on the rise. This group, called “Gram-negative” bacteria, are particularly dangerous and deadly because they are very quick to develop resistance to current treatments. Doctors and nurses don’t have the medical weapons they need to fight these deadly foes.


Public Policy at Work

Public health organizations like the World Health Organization (WHO), the Infectious Disease Society of America (IDSA), along with patient groups, clinicians and industry leaders are working to develop and implement policy changes to help fight the war against superbugs.


Hunting the Nightmare Bacteria

Frontline videoWatch the compelling video from Frontline highlighting the battle against bacteria.

Generating Antibiotics Incentives Now (GAIN) Act

title-viiiThe GAIN Act provides reasonable antibiotic development incentives designed to restore a robust innovation pipeline.

Learn more about GAIN here.

Superbugs and Antibiotic Resistance:
A Guide